Study of the antiarrhythmic activity of linear alkoxyphenylazalkanes in the model of reperfusion arrythmias in rats

The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model reperfusion arrhythmia rats. It found that the key requirements for compounds this are use 2,3,4 trimethoxyphenyl aromatic pharmacophores presence central nitrogen atom linker. most active were ALM-802 (trihydrochloride N –(2,3,4-trimethoxybenzyl)-N – {2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) ALM-811 (N -(2,3,4-trimethoxybenzyl)-N 3 -{3-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,3-propanediamine trihydrochloride), which significantly prevented development ventricular tachycardias and/or fibrillation.